Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition.

TitleFruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition.
Publication TypeJournal Article
Year of Publication2005
AuthorsSchulz, M, Lahmann, PH, Boeing, H, Hoffmann, K, Allen, N, Key, TJA, Bingham, S, Wirfalt, E, Berglund, G, Lundin, E, Hallmans, G, Lukanova, A, Garcia, CMartínez, González, CA, Tormo, MJ, Quirós, JR, Ardanaz, E, Larrañaga, N, Lund, iv, E, Gram, IT, Skeie, G, Peeters, PHM, van Gils, CH, H Bueno-de-Mesquita, B, Büchner, FL, Pasanisi, P, Galasso, R, Palli, D, Tumino, R, Vineis, P, Trichopoulou, A, Kalapothaki, V, Trichopoulos, D, Chang-Claude, J, Linseisen, J, Boutron-Ruault, MChristine, Touillaud, M, Clavel-Chapelon, F, Olsen, A, Tjønneland, A, Overvad, K, Tetsche, M, Jenab, M, Norat, T, Kaaks, R, Riboli, E
JournalCancer Epidemiol Biomarkers Prev
Volume14
Issue11 Pt 1
Pagination2531-5
Date Published2005 Nov
ISSN1055-9965
KeywordsAdult, Aged, Diet, Epidemiologic Studies, Europe, Female, Fruit, Humans, Incidence, Life Style, Middle Aged, Nutrition Surveys, Ovarian Neoplasms, Prospective Studies, Risk Factors, Vegetables
Abstract

OBJECTIVE: The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view.METHODS: Female participants (n = 325,640) of the European Prospective Investigation into Cancer and Nutrition study, free of any cancer at baseline, were followed on average for 6.3 years to develop ovarian cancer. During 2,049,346 person-years, 581 verified cases of primary, invasive epithelial ovarian cancer were accrued. Consumption of fruits and vegetables as well as subgroups of vegetables, estimated from validated dietary questionnaires and calibrated thereafter, was related to ovarian cancer incidence in multivariable hazard regression models. Histologic subtype specific analyses were done.RESULTS: Total intake of fruit and vegetables, separately or combined, as well as subgroups of vegetables (fruiting, root, leafy vegetables, cabbages) was unrelated to risk of ovarian cancer. A high intake of garlic/onion vegetables was associated with a borderline significant reduced risk of this cancer. The examination by histologic subtype indicated some differential effects of fruit and vegetable intake on ovarian cancer risk.CONCLUSION: Overall, a high intake of fruits and vegetables did not seem to protect from ovarian cancer. Garlic/onion vegetables may exert a beneficial effect. The study of the histologic subtype of the tumor warrants further investigation.

DOI10.1158/1055-9965.EPI-05-0159
Alternate JournalCancer Epidemiol. Biomarkers Prev.
Citation Key10.1158/1055-9965.EPI-05-0159
PubMed ID16284374
Grant List / / Wellcome Trust / United Kingdom