Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC).

TitleBody size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Publication TypeJournal Article
Year of Publication2006
AuthorsPischon, T, Lahmann, PH, Boeing, H, Tjønneland, A, Halkjaer, J, Overvad, K, Klipstein-Grobusch, K, Linseisen, J, Becker, N, Trichopoulou, A, Benetou, V, Trichopoulos, D, Sieri, S, Palli, D, Tumino, R, Vineis, P, Panico, S, Monninkhof, E, Peeters, PHM, H Bueno-de-Mesquita, B, Büchner, FL, Ljungberg, B, Hallmans, G, Berglund, G, Gonzalez, CAlberto, Dorronsoro, M, Gurrea, ABarricarte, Navarro, C, Martinez, C, J Quirós, R, Roddam, A, Allen, N, Bingham, S, Khaw, K-T, Kaaks, R, Norat, T, Slimani, N, Riboli, E
JournalInt J Cancer
Volume118
Issue3
Pagination728-38
Date Published2006 Feb 01
ISSN0020-7136
KeywordsBody Composition, Body Height, Body Mass Index, Body Weight, Carcinoma, Renal Cell, Europe, Female, Humans, Incidence, Kidney Neoplasms, Male, Middle Aged, Nutritional Status, Obesity, Risk Factors
Abstract

Previous studies suggest that obesity is related to increased risk of renal cell carcinoma (RCC); however, only a few studies report on measures of central vs. peripheral adiposity. We examined the association between anthropometric measures, including waist and hip circumference and RCC risk among 348,550 men and women free of cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 6.0 years of follow-up we identified 287 incident cases of RCC. Relative risks were calculated using Cox regression, stratified by age and study center and adjusted for smoking status, education, alcohol consumption, physical activity, menopausal status, and hormone replacement therapy use. Among women, an increased risk of RCC was conferred by body weight (relative risk [RR] in highest vs. lowest quintile = 2.13; 95% confidence interval [CI] = 1.16-3.90; p-trend = 0.003), body mass index (BMI) (RR = 2.25; 95% CI = 1.14-4.44; p-trend = 0.009), and waist (RR = 1.67; 95% CI = 0.94-2.98; p-trend = 0.003) and hip circumference (RR = 2.30; 95% CI = 1.22-4.34; p-trend = 0.01); however, waist and hip circumference were no longer significant after controlling for body weight. Among men, hip circumference (RR = 0.44; 95% CI = 0.20-0.98; p-trend = 0.03) was related significantly to decreased RCC risk only after accounting for body weight. Height was not related significantly to RCC risk. Our findings suggest that obesity is related to increased risk of RCC irrespective of fat distribution among women, whereas low hip circumference is related to increased RCC risk among men. Our data give further credence to public health efforts aiming to reduce the prevalence of obesity to prevent RCC, in addition to other chronic diseases.

DOI10.1002/ijc.21398
Alternate JournalInt. J. Cancer
Citation Key10.1002/ijc.21398
PubMed ID16094628
Grant ListG0401527 / / Medical Research Council / United Kingdom