Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

TitleFruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).
Publication TypeJournal Article
Year of Publication2006
AuthorsGonzález, CA, Pera, G, Agudo, A, H Bueno-de-Mesquita, B, Ceroti, M, Boeing, H, Schulz, M, del Giudice, G, Plebani, M, Carneiro, F, Berrino, F, Sacerdote, C, Tumino, R, Panico, S, Berglund, G, Simán, H, Hallmans, G, Stenling, R, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quirós, JR, Allen, N, Key, TJ, Bingham, S, Day, NE, Linseisen, J, Nagel, G, Overvad, K, Jensen, MK, Olsen, A, Tjønneland, A, Büchner, FL, Peeters, PHM, Numans, ME, Clavel-Chapelon, F, Boutron-Ruault, M-C, Roukos, D, Trichopoulou, A, Psaltopoulou, T, Lund, iv, E, Casagrande, C, Slimani, N, Jenab, M, Riboli, E
JournalInt J Cancer
Volume118
Issue10
Pagination2559-66
Date Published2006 May 15
ISSN0020-7136
KeywordsAdenocarcinoma, Adult, Aged, Case-Control Studies, Diet, Esophageal Neoplasms, Europe, Female, Fruit, Helicobacter Infections, Humans, Life Style, Male, Middle Aged, Stomach Neoplasms, Vegetables
Abstract

It is considered that fruit and vegetable (F&V) protect against oesophagus and gastric cancer (GC). However, 2 recent meta-analyses suggest that the strength of association on GC seems to be weaker for vegetables than for fruit and weaker in cohort than in case-control studies. No evidence exists from cohort studies about adenocarcinoma of oesophagus (ACO). In 521,457 men and women participating in the EPIC cohort in 10 European countries, information of diet and lifestyle was collected at baseline. After an average of 6.5 years of follow-up, a total of 330 GC and 65 ACO, confirmed and classified by a panel of pathologists, was used for the analysis. We examined the relation between F&V intake and GC and ACO. A calibration study in a sub-sample was used to control diet measurement errors. In a sub-sample of cases and a random sample of controls, antibodies against Helicobacter pylori (Hp) were measured and interactions with F&V were examined in a nested case-control study. We observed no association with total vegetable intake or specific groups of vegetables and GC risk, except for the intestinal type, where a negative association is possible regarding total vegetable (calibrated HR 0.66; 95% CI 0.35-1.22 per 100 g increase) and onion and garlic intake (calibrated HR 0.70; 95% CI 0.38-1.29 per 10 g increase). No evidence of association between fresh fruit intake and GC risk was observed. We found a negative but non significant association between citrus fruit intake and the cardia site (calibrated HR 0.77; 95% CI 0.47-1.22 per 100 g increase) while no association was observed with the non-cardia site. Regarding ACO, we found a non significant negative association for vegetable intake and for citrus intake (calibrated HRs 0.72; 95% CI 0.32-1.64 and 0.77; 95% CI 0.46-1.28 per 100 and 50 g increase, respectively). It seems that Hp infection does not modify the effect of F&V intake. Our study supports a possible protective role of vegetable intake in the intestinal type of GC and the ACO. Citrus fruit consumption may have a role in the protection against cardia GC and ACO.

DOI10.1002/ijc.21678
Alternate JournalInt. J. Cancer
Citation Key10.1002/ijc.21678
PubMed ID16380980
Grant List / / Wellcome Trust / United Kingdom