Fruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and nutrition (EPIC).

TitleFruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and nutrition (EPIC).
Publication TypeJournal Article
Year of Publication2006
AuthorsWeikert, S, Boeing, H, Pischon, T, Olsen, A, Tjonneland, A, Overvad, K, Becker, N, Linseisen, J, Lahmann, PH, Arvaniti, A, Kassapa, C, Trichoupoulou, A, Sieri, S, Palli, D, Tumino, R, Vineis, P, Panico, S, van Gils, CH, Peeters, PHM, H Bueno-de-Mesquita, B, Büchner, FL, Ljungberg, B, Hallmans, G, Berglund, G, Wirfalt, E, Pera, G, Dorronsoro, M, Gurrea, ABarricarte, Navarro, C, Martinez, C, J Quirós, R, Allen, N, Roddam, A, Bingham, S, Jenab, M, Slimani, N, Norat, T, Riboli, E
JournalInt J Cancer
Volume118
Issue12
Pagination3133-9
Date Published2006 Jun 15
ISSN0020-7136
KeywordsAdult, Aged, Carcinoma, Renal Cell, Europe, Feeding Behavior, Female, Follow-Up Studies, Fruit, Humans, Incidence, Kidney Neoplasms, Life Style, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Proportional Hazards Models, Prospective Studies, Risk Assessment, Risk Factors, Sex Distribution, Sex Factors, Surveys and Questionnaires, Vegetables
Abstract

We examined the association between fruits and vegetables and risk of renal cell carcinoma (RCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary intake data and complete follow-up information on cancer incidence were available for 375,851 participants recruited in EPIC centers of 8 countries. During an average follow-up of 6.2 years, 306 incident cases of RCC were identified. The associations of consumption of total vegetables, total fruits, combined total fruits and vegetables and specific subtypes of vegetables with RCC risk were analyzed using Cox proportional hazards, stratified by centre and adjusted for potential confounders. No significant associations between fruit and vegetable consumption and RCC risk were observed despite a wide range of intake. The estimated relative risks (95% confidence intervals [CI]) in men and women combined were 0.97 (0.85-1.11) per 40 g increase in vegetable intake, 1.03 (0.97-1.08) per 40 g increase in fruit intake and 1.02 (0.93-1.11) per 80 g increase in fruit and vegetable intake combined. Among the vegetable subtypes, an inverse association was observed for root vegetables (RR per 8 g increase: 0.88; 95% CI: 0.78-0.99). These results suggest that total consumption of fruits and vegetables is not related to risk of RCC, although we cannot exclude the possibility that very low consumption is related to higher risk. The relationship of specific fruit and vegetable subgroups with RCC risk warrant further investigation.

DOI10.1002/ijc.21765
Alternate JournalInt. J. Cancer
Citation Key10.1002/ijc.21765
PubMed ID16425278
Grant List / / Wellcome Trust / United Kingdom