Effect of the mitochondrial antioxidant, Mito Vitamin E, on hypoxic-ischemic striatal injury in neonatal rats: a dose-response and stereological study.

TitleEffect of the mitochondrial antioxidant, Mito Vitamin E, on hypoxic-ischemic striatal injury in neonatal rats: a dose-response and stereological study.
Publication TypeJournal Article
Year of Publication2006
AuthorsCovey, MV, Murphy, MP, Hobbs, CE, Smith, RAJ, Oorschot, DE
JournalExp Neurol
Volume199
Issue2
Pagination513-9
Date Published2006 Jun
ISSN0014-4886
KeywordsAnimals, Animals, Newborn, Antioxidants, Corpus Striatum, Dose-Response Relationship, Drug, Female, Hypoxia-Ischemia, Brain, Male, Pregnancy, Rats, Rats, Sprague-Dawley, Stereotaxic Techniques, Vitamin E
Abstract

A mitochondria-targeted antioxidant, Mito Vitamin E (MitoVit E), has previously been shown to prevent mitochondrial oxidative damage. The aim of this study was to investigate the effect of MitoVit E on neuronal survival in the rat striatum after acute perinatal hypoxia-ischemia. Continuous striatal infusion with 4.35 microM, 43.5 microM, or 148 microM of MitoVit E before, during, and after hypoxia-ischemia was not neuroprotective for striatal medium-spiny neurons. Pre- or posttreatment with 435 microM MitoVit E was neurotoxic. These results suggest that MitoVit E is not significantly neuroprotective for striatal medium-spiny neurons after acute perinatal hypoxic-ischemic brain injury. The results also suggest that mitochondrial oxidative damage does not contribute significantly to the death of striatal medium-spiny neurons after perinatal hypoxia-ischemia.

DOI10.1016/j.expneurol.2005.12.026
Alternate JournalExp. Neurol.
Citation Key10.1016/j.expneurol.2005.12.026
PubMed ID16480978
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom