| Title | Effect of the mitochondrial antioxidant, Mito Vitamin E, on hypoxic-ischemic striatal injury in neonatal rats: a dose-response and stereological study. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Covey, MV, Murphy, MP, Hobbs, CE, Smith, RAJ, Oorschot, DE |
| Journal | Exp Neurol |
| Volume | 199 |
| Issue | 2 |
| Pagination | 513-9 |
| Date Published | 2006 Jun |
| ISSN | 0014-4886 |
| Keywords | Animals, Animals, Newborn, Antioxidants, Corpus Striatum, Dose-Response Relationship, Drug, Female, Hypoxia-Ischemia, Brain, Male, Pregnancy, Rats, Rats, Sprague-Dawley, Stereotaxic Techniques, Vitamin E |
| Abstract | A mitochondria-targeted antioxidant, Mito Vitamin E (MitoVit E), has previously been shown to prevent mitochondrial oxidative damage. The aim of this study was to investigate the effect of MitoVit E on neuronal survival in the rat striatum after acute perinatal hypoxia-ischemia. Continuous striatal infusion with 4.35 microM, 43.5 microM, or 148 microM of MitoVit E before, during, and after hypoxia-ischemia was not neuroprotective for striatal medium-spiny neurons. Pre- or posttreatment with 435 microM MitoVit E was neurotoxic. These results suggest that MitoVit E is not significantly neuroprotective for striatal medium-spiny neurons after acute perinatal hypoxic-ischemic brain injury. The results also suggest that mitochondrial oxidative damage does not contribute significantly to the death of striatal medium-spiny neurons after perinatal hypoxia-ischemia. |
| DOI | 10.1016/j.expneurol.2005.12.026 |
| Alternate Journal | Exp. Neurol. |
| Citation Key | 10.1016/j.expneurol.2005.12.026 |
| PubMed ID | 16480978 |
| Grant List | MC_U105663142 / / Medical Research Council / United Kingdom |
