Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.

TitleEndogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study.
Publication TypeJournal Article
Year of Publication2006
AuthorsJakszyn, P, Bingham, S, Pera, G, Agudo, A, Luben, R, Welch, A, Boeing, H, del Giudice, G, Palli, D, Saieva, C, Krogh, V, Sacerdote, C, Tumino, R, Panico, S, Berglund, G, Simán, H, Hallmans, G, Sanchez, MJosé, Larrañaga, N, Barricarte, A, Chirlaque, MDolores, Quirós, JR, Key, TJ, Allen, N, Lund, iv, E, Carneiro, F, Linseisen, J, Nagel, G, Overvad, K, Tjonneland, A, Olsen, A, H Bueno-de-Mesquita, B, Ocké, MO, Peeters, PHm, Numans, ME, Clavel-Chapelon, F, Trichopoulou, A, Fenger, C, Stenling, R, Ferrari, P, Jenab, M, Norat, T, Riboli, E, González, CA
JournalCarcinogenesis
Volume27
Issue7
Pagination1497-501
Date Published2006 Jul
ISSN0143-3334
KeywordsAdenocarcinoma, Animals, Ascorbic Acid, Case-Control Studies, Cattle, Diet, Dimethylnitrosamine, Europe, Female, Helicobacter Infections, Helicobacter pylori, Humans, Iron, Male, Meat, Middle Aged, Nitrosamines, Prospective Studies, Risk Factors, Stomach Neoplasms
Abstract

The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was

DOI10.1093/carcin/bgl019
Alternate JournalCarcinogenesis
Citation Key10.1093/carcin/bgl019
PubMed ID16571648
Grant List / / Wellcome Trust / United Kingdom