Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study.

TitleIntake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study.
Publication TypeJournal Article
Year of Publication2006
AuthorsBoeing, H, Dietrich, T, Hoffmann, K, Pischon, T, Ferrari, P, Lahmann, PH, Boutron-Ruault, MChristine, Clavel-Chapelon, F, Allen, N, Key, T, Skeie, G, Lund, iv, E, Olsen, A, Tjonneland, A, Overvad, K, Jensen, MK, Rohrmann, S, Linseisen, J, Trichopoulou, A, Bamia, C, Psaltopoulou, T, Weinehall, L, Johansson, I, Sánchez, M-J, Jakszyn, P, Ardanaz, E, Amiano, P, Chirlaque, MDolores, J Quirós, R, Wirfalt, E, Berglund, G, Peeters, PH, van Gils, CH, H Bueno-de-Mesquita, B, Büchner, FL, Berrino, F, Palli, D, Sacerdote, C, Tumino, R, Panico, S, Bingham, S, Khaw, K-T, Slimani, N, Norat, T, Jenab, M, Riboli, E
JournalCancer Causes Control
Date Published2006 Sep
KeywordsCarcinoma, Squamous Cell, Cohort Studies, Diet, Esophageal Neoplasms, Female, Fruit, Humans, Incidence, Laryngeal Neoplasms, Male, Mouth Neoplasms, Pharyngeal Neoplasms, Prospective Studies, Risk Factors, Vegetables

Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (<120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake.

Alternate JournalCancer Causes Control
Citation Key10.1007/s10552-006-0036-4
PubMed ID16841263
Grant ListG0401527 / / Medical Research Council / United Kingdom