Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition.

TitlePlasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition.
Publication TypeJournal Article
Year of Publication2006
AuthorsJenab, M, Riboli, E, Ferrari, P, Friesen, M, Sabate, J, Norat, T, Slimani, N, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M-C, Clavel-Chapelon, F, Boeing, H, Schulz, M, Linseisen, J, Nagel, G, Trichopoulou, A, Naska, A, Oikonomou, E, Berrino, F, Panico, S, Palli, D, Sacerdote, C, Tumino, R, Peeters, PH, Numans, ME, Bueno-de-Mesquita, HB, Büchner, FL, Lund, E, Pera, G, Chirlaque, MD, Sánchez, M-J, Arriola, L, Barricarte, A, Quiros, JR, Johansson, I, Johansson, A, Berglund, G, Bingham, S, Khaw, K-T, Allen, N, Key, T, Carneiro, F, Save, V, Del Giudice, G, Plebani, M, Kaaks, R, González, CA
JournalBr J Cancer
Volume95
Issue3
Pagination406-15
Date Published2006 Aug 07
ISSN0007-0920
KeywordsAdenocarcinoma, Adult, Aged, Carotenoids, Case-Control Studies, Diet, Europe, Follow-Up Studies, Humans, Middle Aged, Nutritional Physiological Phenomena, Prospective Studies, Risk Factors, Stomach Neoplasms, Tocopherols, Vitamin A
Abstract

Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and alpha- and gamma-tocopherol, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 countries. A secondary objective was to determine the association of total sum of carotenoids, retinol and alpha-tocopherol on GCs by anatomical subsite (cardia/noncardia) and histological subtype (diffuse/intestinal). Analytes were measured by high-performance liquid chromatography in prediagnostic plasma from 244 GC cases and 645 controls matched by age, gender, study centre and date of blood donation. Conditional logistic regression models adjusted by body mass index, total energy intake, smoking and Helicobacter pylori infection status were used to estimate relative cancer risks. After an average 3.2 years of follow-up, a negative association with GC risk was observed in the highest vs the lowest quartiles of plasma beta-cryptoxanthin (odds ratio (OR) = 0.53, 95% confidence intervals (CI) = 0.30-0.94, P(trend) = 0.006), zeaxanthin (OR = 0.39, 95% CI = 0.22-0.69, P(trend) = 0.005), retinol (OR = 0.55, 95% CI = 0.33-0.93, P(trend) = 0.005) and lipid-unadjusted alpha-tocopherol (OR = 0.59, 95% CI = 0.37-0.94, P(trend) = 0.022). For all analytes, no heterogeneity of risk estimates or significant associations were observed by anatomical subsite. In the diffuse histological subtype, an inverse association was observed with the highest vs lowest quartile of lipid-unadjusted alpha-tocopherol (OR = 0.26, 95% CI = 0.11-0.65, P(trend) = 0.003). These results show that higher plasma concentrations of some carotenoids, retinol and alpha-tocopherol are associated with reduced risk of GC.

DOI10.1038/sj.bjc.6603266
Alternate JournalBr. J. Cancer
Citation Key10.1038/sj.bjc.6603266
PubMed ID16832408
PubMed Central IDPMC2360629
Grant ListG0401527 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom