Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.

TitleApolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study.
Publication TypeJournal Article
Year of Publication2006
AuthorsVaessen, SFC, Schaap, FG, Kuivenhoven, J-A, Groen, AK, Hutten, BA, S Boekholdt, M, Hattori, H, Sandhu, MS, Bingham, SA, Luben, R, Palmen, JA, Wareham, NJ, Humphries, SE, Kastelein, JJP, Talmud, PJ, Khaw, K-T
JournalJ Lipid Res
Volume47
Issue9
Pagination2064-70
Date Published2006 Sep
ISSN0022-2275
KeywordsAged, Apolipoprotein A-V, Apolipoproteins, Apolipoproteins A, Case-Control Studies, Coronary Artery Disease, Female, Gene Frequency, Genotype, Humans, Linkage Disequilibrium, Male, Middle Aged, Multivariate Analysis, Polymorphism, Single Nucleotide, Prospective Studies, Risk Factors, Triglycerides, United Kingdom
Abstract

In mouse models, apolipoprotein A-V (apoA-V) exhibits triglyceride (TG)-lowering effects. We investigated the apoA-V/TG relationship and the association of apoA-V with coronary artery disease (CAD) risk by determining serum apoA-V levels and genotypes in a nested case-control (n = 1,034/2,031) study. Both univariate and multivariate apoA-V levels showed no association with future CAD (P = 0.4 and 0.5, respectively). Unexpectedly, there was a significant positive correlation between serum apoA-V and TG in men and women (r = 0.36 and 0.28, respectively, P < 0.001 each) but a negative correlation between apoA-V and LPL mass (r = -0.14 and -0.12 for men and women respectively, P < 0.001 each). The frequency of the c.56C>G polymorphism did not differ between cases and controls despite significant positive association of c.56G with both apoA-V and TG levels. For -1131T>C, the minor allele was significantly associated with lower apoA-V yet higher TG levels and was overrepresented in cases (P = 0.047). The association of -1131T>C with CAD risk, however, was independent of apoA-V levels and likely acts through linkage disequilibrium with APOC3 variants. The positive correlation of apoA-V levels with TG levels, negative correlation with LPL levels, and lack of association with CAD risk highlight the need for further human studies to clarify the role of apoA-V.

DOI10.1194/jlr.M600233-JLR200
Alternate JournalJ. Lipid Res.
Citation Key10.1194/jlr.M600233-JLR200
PubMed ID16769999
Grant ListG0401527 / / Medical Research Council / United Kingdom
MC_U106179471 / / Medical Research Council / United Kingdom