Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

TitleTissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.
Publication TypeJournal Article
Year of Publication2006
AuthorsKeller, TT, Choi, D, Nagel, C, H Velthuis, T, Gerdes, VEA, Wareham, NJ, Bingham, SA, Luben, R, Hack, CE, Reitsma, PH, Levi, M, Khaw, KT, Boekholdt, SM
JournalJ Thromb Haemost
Volume4
Issue11
Pagination2391-6
Date Published2006 Nov
ISSN1538-7933
KeywordsAged, Blood Pressure, C-Reactive Protein, Case-Control Studies, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Incidence, Lipoproteins, HDL, Lipoproteins, LDL, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Risk Factors, Smoking, Thromboplastin
Abstract

INTRODUCTION: Tissue factor (TF) has been implicated in coronary artery disease (CAD). High levels of circulating TF are found in patients with acute atherothrombotic events. Whether high serum TF levels predict risk of future CAD independent of known risk factors remains unknown.METHODS: We conducted a prospective case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk population study. Cases (n=1037) were apparently healthy men and women, aged 45-79 years, who developed fatal or non-fatal CAD during follow-up. Controls (n=2005) were matched by age, sex, and enrolment time. Serum TF levels were measured using high-affinity antibodies.RESULTS: In men, median TF levels were not significant higher in cases than in controls (59.0 pg mL-1, range: 16.7-370.4 vs. 54.9 pg mL-1, range: 16.2-452.4). In women, median TF levels were not significant higher in controls than in cases (73.4 pg mL-1, range: 16.7-492.3 vs. 50.5 pg mL-1, range: 16.5-376.7). The incidence of smoking was about double in the lowest compared with the highest TF quartile. Correcting for sex, age, body mass index, smoking, diabetes, systolic blood pressure, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol and C-reactive protein levels, the risk of future CAD was 1.05 (95% CI: 0.81-1.36) for people in the highest TF quartile, compared with those in the lowest (P-value for linearity=0.8).CONCLUSION: High levels of serum TF were not independently associated with an increased risk of future CAD in apparently healthy individuals.

DOI10.1111/j.1538-7836.2006.02190.x
Alternate JournalJ. Thromb. Haemost.
Citation Key10.1111/j.1538-7836.2006.02190.x
PubMed ID16938131
Grant ListG0401527 / / Medical Research Council / United Kingdom
MC_U106179471 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom