Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

TitlePlasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).
Publication TypeJournal Article
Year of Publication2006
AuthorsJenab, M, Riboli, E, Ferrari, P, Sabate, J, Slimani, N, Norat, T, Friesen, M, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M-C, Clavel-Chapelon, F, Touvier, M, Boeing, H, Schulz, M, Linseisen, J, Nagel, G, Trichopoulou, A, Naska, A, Oikonomou, E, Krogh, V, Panico, S, Masala, G, Sacerdote, C, Tumino, R, Peeters, PH, Numans, ME, Bueno-de-Mesquita, HB, Büchner, FL, Lund, iv, E, Pera, G, Sanchez, CNavarro, Sánchez, M-J, Arriola, L, Barricarte, A, Quirós, JRamón, Hallmans, G, Stenling, R, Berglund, G, Bingham, S, Khaw, K-T, Key, T, Allen, N, Carneiro, F, Mahlke, U, Del Giudice, G, Palli, D, Kaaks, R, González, CA
JournalCarcinogenesis
Volume27
Issue11
Pagination2250-7
Date Published2006 Nov
ISSN0143-3334
KeywordsAged, Ascorbic Acid, Case-Control Studies, Cohort Studies, Dietary Supplements, Europe, Female, Helicobacter pylori, Humans, Incidence, Logistic Models, Male, Middle Aged, Prospective Studies, Stomach Neoplasms
Abstract

Vitamin C is an antioxidant and inhibitor of carcinogenic N-nitroso compound production in the stomach. Higher dietary vitamin C consumption is associated with decreased risk of gastric cancer (GC) in numerous case-control studies, but data from prospective studies are limited, particularly so for blood measures of vitamin C. The objective of this study was to determine the association of plasma and dietary vitamin C levels with the risk of GC in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 European countries. Using a fluorometric method, vitamin C was measured in pre-diagnostic plasma from 215 GC cases (matched controls = 416). Conditional logistic regression models adjusted by body mass index, total energy intake, smoking status/duration/intensity and Helicobacter pylori infection status were used to estimate relative cancer risks. No association with GC risk was observed for dietary vitamin C, whereas an inverse GC risk was observed in the highest versus lowest quartile of plasma vitamin C [odds ratio (OR) = 0.55, 95% confidence interval (CI) = 0.31-0.97, P(trend) = 0.043], which was maintained after exclusion of cases with

DOI10.1093/carcin/bgl096
Alternate JournalCarcinogenesis
Citation Key10.1093/carcin/bgl096
PubMed ID16774936
Grant ListG0401527 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom