|Title||New marker of colon cancer risk associated with heme intake: 1,4-dihydroxynonane mercapturic acid.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Pierre, F, Peiro, G, Taché, S, Cross, AJ, Bingham, SA, Gasc, N, Gottardi, G, Corpet, DE, Guéraud, F|
|Journal||Cancer Epidemiol Biomarkers Prev|
|Date Published||2006 Nov|
|Keywords||Acetylcysteine, Adult, Aged, Animal Feed, Animals, Colonic Neoplasms, Diet, Female, Heme, Humans, Iron, Male, Middle Aged, Oxidative Stress, Rats, Rats, Inbred F344, Risk, Tumor Markers, Biological|
BACKGROUND: Red meat consumption is associated with an increased risk of colon cancer. Animal studies show that heme, found in red meat, promotes preneoplastic lesions in the colon, probably due to the oxidative properties of this compound. End products of lipid peroxidation, such as 4-hydroxynonenal metabolites or 8-iso-prostaglandin-F(2)alpha (8-iso-PGF(2)alpha), could reflect this oxidative process and could be used as biomarkers of colon cancer risk associated with heme intake.
METHODS: We measured urinary excretion of 8-iso-PGF(2)alpha and 1,4-dihydroxynonane mercapturic acid (DHN-MA), the major urinary metabolite of 4-hydroxynonenal, in three studies. In a short-term and a carcinogenesis long-term animal study, we fed rats four different diets (control, chicken, beef, and blood sausage as a high heme diet). In a randomized crossover human study, four different diets were fed (a 60 g/d red meat baseline diet, 120 g/d red meat, baseline diet supplemented with heme iron, and baseline diet supplemented with non-heme iron).
RESULTS: DHN-MA excretion increased dramatically in rats fed high heme diets, and the excretion paralleled the number of preneoplastic lesions in azoxymethane initiated rats (P
CONCLUSION: Urinary DHN-MA is a useful noninvasive biomarker for determining the risk of preneoplastic lesions associated with heme iron consumption and should be further investigated as a potential biomarker of colon cancer risk.
|Alternate Journal||Cancer Epidemiol. Biomarkers Prev.|