Variations in plasma phytoestrogen concentrations in European adults.

TitleVariations in plasma phytoestrogen concentrations in European adults.
Publication TypeJournal Article
Year of Publication2007
AuthorsPeeters, PHM, Slimani, N, van der Schouw, YT, Grace, PB, Navarro, C, Tjonneland, A, Olsen, A, Clavel-Chapelon, F, Touillaud, M, Boutron-Ruault, M-C, Jenab, M, Kaaks, R, Linseisen, J, Trichopoulou, A, Trichopoulos, D, Dilis, V, Boeing, H, Weikert, C, Overvad, K, Pala, V, Palli, D, Panico, S, Tumino, R, Vineis, P, H Bueno-de-Mesquita, B, van Gils, CH, Skeie, G, Jakszyn, P, Hallmans, G, Berglund, G, Key, TJ, Travis, R, Riboli, E, Bingham, SA
JournalJ Nutr
Volume137
Issue5
Pagination1294-300
Date Published2007 May
ISSN0022-3166
KeywordsCohort Studies, Diet, Vegetarian, Europe, Female, Humans, Isoflavones, Lignans, Male, Middle Aged, Multivariate Analysis, Osmolar Concentration, Phytoestrogens, Prospective Studies
Abstract

Dietary phytoestrogens may play a role in chronic disease occurrence. The aim of our study was to assess the variability of plasma concentrations in European populations. We included 15 geographical regions in 9 European countries (Denmark, France, Germany, Greece, Italy, Spain, Sweden, The Netherlands, and UK) and a 16th region, Oxford, UK, where participants were recruited from among vegans and vegetarians. All subjects were participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma concentrations of 3 isoflavones (daidzein, genistein, and glycitein), 2 metabolites of daidzein [O-desmethylangolensin (O-DMA) and equol] and 2 mammalian lignans (enterodiol and enterolactone) were measured in 1414 participants. We computed geometric means for each region and used multivariate regression analysis to assess the influence of region, adjusted for gender, age, BMI, alcohol intake, smoking status, and laboratory batch. Many subjects had concentrations below the detection limit [0.1 microg/L (0.4 nmol/L)] for glycitein (80%), O-DMA (73%) and equol (62%). Excluding subjects from Oxford, UK, the highest concentrations of isoflavones were in subjects from the Netherlands and Cambridge, UK [2-6 microg/L (7-24 nmol/L); P < 0.05], whereas concentrations for lignans were highest in Denmark [8 microg/L (27 nmol/L); P < 0.05]. Isoflavones varied 8- to 13-fold, whereas lignans varied 4-fold. In the vegetarian/vegan cohort of Oxford, concentrations of isoflavones were 5-50 times higher than in nonvegetarian regions. Region was the most important determinant of plasma concentrations for all 7 phytoestrogens. Despite the fact that plasma concentrations of phytoestrogens in Europe were low compared with Asian populations, they varied substantially among subjects from the 16 different regions.

DOI10.1093/jn/137.5.1294
Alternate JournalJ. Nutr.
Citation Key10.1093/jn/137.5.1294
PubMed ID17449595
Grant ListMC_U105630924 / / Medical Research Council / United Kingdom
R03 CA099846 / CA / NCI NIH HHS / United States
/ / Wellcome Trust / United Kingdom