Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition.

TitleSerum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition.
Publication TypeJournal Article
Year of Publication2007
AuthorsJenab, M, Riboli, E, Cleveland, RJ, Norat, T, Rinaldi, S, Nieters, A, Biessy, C, Tjønneland, A, Olsen, A, Overvad, K, Grønbaek, H, Clavel-Chapelon, F, Boutron-Ruault, M-C, Linseisen, J, Boeing, H, Pischon, T, Trichopoulos, D, Oikonomou, E, Trichopoulou, A, Panico, S, Vineis, P, Berrino, F, Tumino, R, Masala, G, Peters, PH, van Gils, CH, H Bueno-de-Mesquita, B, Ocké, MC, Lund, iv, E, Mendez, MA, Tormo, MJosé, Barricarte, A, Martínez-García, C, Dorronsoro, M, Quirós, JRamón, Hallmans, G, Palmqvist, R, Berglund, G, Manjer, J, Key, T, Allen, NE, Bingham, S, Khaw, K-T, Cust, A, Kaaks, R
JournalInt J Cancer
Volume121
Issue2
Pagination368-76
Date Published2007 Jul 15
ISSN0020-7136
KeywordsAdult, Aged, Aged, 80 and over, Body Mass Index, C-Peptide, Case-Control Studies, Europe, Female, Follow-Up Studies, Humans, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 2, Logistic Models, Male, Middle Aged, Prospective Studies, Rectal Neoplasms, Risk Factors
Abstract

Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF-I and decreasing the bioactivity of some of its binding proteins. The objective of this study was to determine the association of increasing levels of serum C-peptide, a biomarker of pancreatic insulin secretion, and IGF binding proteins (IGFBP) -1 and -2 with colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 Western European countries. A total of 1,078 colorectal cancer cases were matched (age, date of blood donation, fasting status, gender, study center) to an equal number of control subjects. Relative cancer risks were estimated using conditional logistic regression models. Serum C-peptide concentration was positively associated with an increased colorectal cancer risk for the highest versus the lowest quintile (OR=1.56, 95% CI=1.16-2.09, p(trend)

DOI10.1002/ijc.22697
Alternate JournalInt. J. Cancer
Citation Key10.1002/ijc.22697
PubMed ID17372899
Grant List1R01CA102460 / CA / NCI NIH HHS / United States
G0401527 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom