Self-reported mental health-related quality of life and mortality in men and women in the European Prospective Investigation into Cancer (EPIC-Norfolk): a prospective population study.

TitleSelf-reported mental health-related quality of life and mortality in men and women in the European Prospective Investigation into Cancer (EPIC-Norfolk): a prospective population study.
Publication TypeJournal Article
Year of Publication2007
AuthorsMyint, PK, Luben, RN, Surtees, PG, Wainwright, NWJ, Welch, AA, Bingham, SA, Wareham, NJ, Smith, RD, Harvey, IM, Khaw, K-T
JournalPsychosom Med
Volume69
Issue5
Pagination410-4
Date Published2007 Jun
ISSN1534-7796
KeywordsAdult, Aged, Cardiovascular Diseases, England, Female, Humans, Male, Mental Health, Middle Aged, Mortality, Neoplasms, Prospective Studies, Quality of Life
Abstract

OBJECTIVE: To explore the relationship between self-reported mental functional health and mortality.METHODS: Participants included 17,777 men and women aged 40 to 79 years at baseline who lived in Norfolk, UK, and had no known cardiovascular disease or cancer, and completed the anglicized Short Form 36-item questionnaire (UK SF-36) during 1996 to 2000 in the European Prospective Investigation into Cancer-Norfolk prospective population study. We examined the relationship between mental functional health derived from the mental component summary scores of the SF-36 and mortality from all causes, cardiovascular disease, cancer, and other causes during an average 6.5-year follow-up.RESULTS: There were 1065 deaths during a total of 115,550 person-years of follow-up. Impaired mental health-related quality of life was associated with increased risk of all-cause mortality in men and women. A decrease of 1 SD (10 points) in SF-36 mental component summary scores was associated with a 14% increase in all-cause mortality (hazards ratio = 1.14; 95% Confidence Interval: 1.07, 1.21) after controlling for age, gender, body mass index, systolic blood pressure, cholesterol, alcohol consumption, diabetes, smoking, social class, and physical functional health.CONCLUSION: Poor self-reported mental functional health is related to increased risk of all-cause mortality in men and women. Interpretation of this association requires further investigation.

DOI10.1097/psy.0b013e318068fcd4
Alternate JournalPsychosom Med
Citation Key10.1097/psy.0b013e318068fcd4
PubMed ID17585062
Grant ListG0300128 / / Medical Research Council / United Kingdom
G0401527 / / Medical Research Council / United Kingdom
MC_U106179471 / / Medical Research Council / United Kingdom