Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition.

TitleAnthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition.
Publication TypeJournal Article
Year of Publication2007
AuthorsFriedenreich, C, Cust, A, Lahmann, PH, Steindorf, K, Boutron-Ruault, M-C, Clavel-Chapelon, F, Mesrine, S, Linseisen, J, Rohrmann, S, Boeing, H, Pischon, T, Tjønneland, A, Halkjaer, J, Overvad, K, Mendez, M, Redondo, ML, Garcia, CMartinez, Larrañaga, N, Tormo, M-J, Gurrea, ABarricarte, Bingham, S, Khaw, K-T, Allen, N, Key, T, Trichopoulou, A, Vasilopoulou, E, Trichopoulos, D, Pala, V, Palli, D, Tumino, R, Mattiello, A, Vineis, P, H Bueno-de-Mesquita, B, Peeters, PHM, Berglund, G, Manjer, J, Lundin, E, Lukanova, A, Slimani, N, Jenab, M, Kaaks, R, Riboli, E
JournalCancer Causes Control
Volume18
Issue4
Pagination399-413
Date Published2007 May
ISSN0957-5243
KeywordsAdiposity, Anthropometry, Body Mass Index, Endometrial Neoplasms, Europe, Female, Hormone Replacement Therapy, Humans, Incidence, Menopause, Middle Aged, Nutrition Assessment, Nutritional Status, Obesity, Prospective Studies, Risk, Risk Factors
Abstract

OBJECTIVE: To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups.METHODS: Among 223,008 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, there were 567 incident endometrial cancer cases during 6.4 years of follow-up. The analysis was performed with Cox proportional hazards modeling.RESULTS: Weight, body mass index (BMI), waist and hip circumferences and waist-hip ratio (WHR) were strongly associated with increased risk of endometrial cancer. The relative risk (RR) for obese (BMI 30- < 40 kg/m(2)) compared to normal weight (BMI < 25) women was 1.78, 95% CI = 1.41-2.26, and for morbidly obese women (BMI > or = 40) was 3.02, 95% CI = 1.66-5.52. The RR for women with a waist circumference of > or =88 cm vs. <80 cm was 1.76, 95% CI = 1.42-2.19. Adult weight gain of > or =20 kg compared with stable weight (+/-3 kg) increased risk independent of body weight at age 20 (RR = 1.75, 95% CI = 1.11-2.77). These associations were generally stronger for postmenopausal than premenopausal women, and oral contraceptives never-users than ever-users, and much stronger among never-users of hormone replacement therapy compared to ever-users.CONCLUSION: Obesity, abdominal adiposity, and adult weight gain were strongly associated with endometrial cancer risk. These associations were particularly evident among never-users of hormone replacement therapy.

DOI10.1007/s10552-006-0113-8
Alternate JournalCancer Causes Control
Citation Key10.1007/s10552-006-0113-8
PubMed ID17297555
Grant ListG0401527 / / Medical Research Council / United Kingdom