Endogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC).

TitleEndogenous sex hormones and endometrial cancer risk in women in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Publication TypeJournal Article
Year of Publication2008
AuthorsAllen, NE, Key, TJ, Dossus, L, Rinaldi, S, Cust, A, Lukanova, A, Peeters, PH, N Onland-Moret, C, Lahmann, PH, Berrino, F, Panico, S, Larrañaga, N, Pera, G, Tormo, M-J, Sánchez, M-J, J Quirós, R, Ardanaz, E, Tjønneland, A, Olsen, A, Chang-Claude, J, Linseisen, J, Schulz, M, Boeing, H, Lundin, E, Palli, D, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, M-C, Bingham, S, Khaw, K-T, H Bueno-de-Mesquita, B, Trichopoulou, A, Trichopoulos, D, Naska, A, Tumino, R, Riboli, E, Kaaks, R
JournalEndocr Relat Cancer
Volume15
Issue2
Pagination485-97
Date Published2008 Jun
ISSN1351-0088
KeywordsAdult, Aged, Androstenedione, Body Mass Index, Dehydroepiandrosterone Sulfate, Endometrial Neoplasms, Estradiol, Estrone, Europe, Female, Gonadal Steroid Hormones, Humans, Incidence, Middle Aged, Odds Ratio, Postmenopause, Premenopause, Prospective Studies, Risk Factors, Sex Hormone-Binding Globulin, Testosterone
Abstract

Epidemiological data show that reproductive and hormonal factors are involved in the etiology of endometrial cancer, but there is little data on the association with endogenous sex hormone levels. We analyzed the association between prediagnostic serum concentrations of sex steroids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition using a nested case-control design of 247 incident endometrial cancer cases and 481 controls, matched on center, menopausal status, age, variables relating to blood collection, and, for premenopausal women, phase of menstrual cycle. Using conditional regression analysis, endometrial cancer risk among postmenopausal women was positively associated with increasing levels of total testosterone, free testosterone, estrone, total estradiol, and free estradiol. The odds ratios (ORs) for the highest versus lowest tertile were 2.66 (95% confidence interval (CI) 1.50-4.72; P=0.002 for a continuous linear trend) for estrone, 2.07 (95% CI 1.20-3.60; P=0.001) for estradiol, and 1.66 (95% CI 0.98-2.82; P=0.001) for free estradiol. For total and free testosterone, ORs for the highest versus lowest tertile were 1.44 (95% CI 0.88-2.36; P=0.05) and 2.05 (95% CI 1.23-3.42; P=0.005) respectively. Androstenedione and dehydroepiandrosterone sulfate were not associated with risk. Sex hormone-binding globulin was significantly inversely associated with risk (OR for the highest versus lowest tertile was 0.57, 95% CI 0.34-0.95; P=0.004). In premenopausal women, serum sex hormone concentrations were not clearly associated with endometrial cancer risk, but numbers were too small to draw firm conclusions. In conclusion, relatively high blood concentrations of estrogens and free testosterone are associated with an increased endometrial cancer risk in postmenopausal women.

DOI10.1677/ERC-07-0064
Alternate JournalEndocr. Relat. Cancer
Citation Key10.1677/ERC-07-0064
PubMed ID18509001
PubMed Central IDPMC2396334
Grant List / / British Heart Foundation / United Kingdom
/ / Department of Health / United Kingdom
/ / Cancer Research UK / United Kingdom
G0401527 / / Medical Research Council / United Kingdom
MC_U105960384 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom