The efficiency of cellular energy transduction and its implications for obesity.

TitleThe efficiency of cellular energy transduction and its implications for obesity.
Publication TypeJournal Article
Year of Publication2008
AuthorsHarper, M-E, Green, K, Brand, MD
JournalAnnu Rev Nutr
Volume28
Pagination13-33
Date Published2008
ISSN0199-9885
KeywordsAdenosine Triphosphate, Basal Metabolism, Energy Metabolism, Humans, Mitochondria, Obesity, Signal Transduction, Uncoupling Agents
Abstract

We assess the existence, mechanism, and functions of less-than-maximal coupling efficiency of mitochondrial oxidative phosphorylation and its potential as a target for future antiobesity interventions. Coupling efficiency is the proportion of oxygen consumption used to make adenosine triphosphate (ATP) and do useful work. High coupling efficiency may lead to fat deposition; low coupling efficiency to a decrease in fat stores. We review obligatory and facultative energy expenditure and the role of a futile cycle of proton pumping and proton leak across the mitochondrial inner membrane in dissipating energy. Basal proton conductance is catalyzed primarily by the adenine nucleotide translocase but can be mimicked by chemical uncouplers. Inducible proton conductance is catalyzed by specific uncoupling proteins. We discuss the opportunities and pitfalls of targeting these processes as a treatment for obesity by decreasing coupling efficiency and increasing energy expenditure, either directly or through central mechanisms of energy homeostasis.

DOI10.1146/annurev.nutr.28.061807.155357
Alternate JournalAnnu. Rev. Nutr.
Citation Key10.1146/annurev.nutr.28.061807.155357
PubMed ID18407744
Grant List / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom