Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study.

TitleBulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study.
Publication TypeJournal Article
Year of Publication2008
AuthorsPeluso, M, Airoldi, L, Munnia, A, Colombi, A, Veglia, F, Autrup, H, Dunning, A, Garte, S, Gormally, E, Malaveille, C, Matullo, G, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulou, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-de-Mesquita, BH, Peeters, PH, Kumle, M, Agudo, A, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, MJosé, Quirós, JRamón, Berglund, G, Jarvholm, B, Day, NE, Key, TJ, Saracci, R, Kaaks, R, Riboli, E, Bingham, S, Vineis, P
JournalBr J Nutr
Volume100
Issue3
Pagination489-95
Date Published2008 Sep
ISSN1475-2662
KeywordsAged, Air Pollutants, Alcohol Drinking, Biomarkers, Body Mass Index, Carcinogens, Colonic Neoplasms, Dietary Fiber, DNA Adducts, Erythrocytes, Europe, Fabaceae, Female, Fruit, Hemoglobins, Humans, Leukocytes, Male, Middle Aged, Multivariate Analysis, Nutritional Physiological Phenomena, Ozone, Prospective Studies, Vegetables
Abstract

In contrast to some extensively examined food mutagens, for example, aflatoxins, N-nitrosamines and heterocyclic amines, some other food contaminants, in particular polycyclic aromatic hydrocarbons (PAH) and other aromatic compounds, have received less attention. Therefore, exploring the relationships between dietary habits and the levels of biomarkers related to exposure to aromatic compounds is highly relevant. We have investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort the association between dietary items (food groups and nutrients) and aromatic DNA adducts and 4-aminobiphenyl-Hb adducts. Both types of adducts are biomarkers of carcinogen exposure and possibly of cancer risk, and were measured, respectively, in leucocytes and erythrocytes of 1086 (DNA adducts) and 190 (Hb adducts) non-smokers. An inverse, statistically significant, association has been found between DNA adduct levels and dietary fibre intake (P = 0.02), vitamin E (P = 0.04) and alcohol (P = 0.03) but not with other nutrients or food groups. Also, an inverse association between fibre and fruit intake, and BMI and 4-aminobiphenyl-Hb adducts (P = 0.03, 0.04, and 0.03 respectively) was observed. After multivariate regression analysis these inverse correlations remained statistically significant, except for the correlation adducts v. fruit intake. The present study suggests that fibre intake in the usual range can modify the level of DNA or Hb aromatic adducts, but such role seems to be quantitatively modest. Fibres could reduce the formation of DNA adducts in different manners, by diluting potential food mutagens and carcinogens in the gastrointestinal tract, by speeding their transit through the colon and by binding carcinogenic substances.

DOI10.1017/S0007114508911600
Alternate JournalBr. J. Nutr.
Citation Key10.1017/S0007114508911600
PubMed ID18275627
Grant List / / Wellcome Trust / United Kingdom
/ / Department of Health / United Kingdom
/ / Medical Research Council / United Kingdom
/ / British Heart Foundation / United Kingdom