Mitochondria-targeted antioxidants in the treatment of disease.

TitleMitochondria-targeted antioxidants in the treatment of disease.
Publication TypeJournal Article
Year of Publication2008
AuthorsSmith, RAJ, Adlam, VJ, Blaikie, FH, Manas, A-RB, Porteous, CM, James, AM, Ross, MF, Logan, A, Cochemé, HM, Trnka, J, Prime, TA, Abakumova, I, Jones, BA, Filipovska, A, Murphy, MP
JournalAnn N Y Acad Sci
Volume1147
Pagination105-11
Date Published2008 Dec
ISSN1749-6632
KeywordsAntioxidants, Humans, Mitochondria, Oxidative Stress
Abstract

Mitochondrial oxidative damage is thought to contribute to a wide range of human diseases; therefore, the development of approaches to decrease this damage may have therapeutic potential. Mitochondria-targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death have been developed. These compounds contain antioxidant moieties, such as ubiquinone, tocopherol, or nitroxide, that are targeted to mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation. Because of the large mitochondrial membrane potential, the cations are accumulated within the mitochondria inside cells. There, the conjugated antioxidant moiety protects mitochondria from oxidative damage. Here, we outline some of the work done to date on these compounds and how they may be developed as therapies.

DOI10.1196/annals.1427.003
Alternate JournalAnn. N. Y. Acad. Sci.
Citation Key10.1196/annals.1427.003
PubMed ID19076435
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom