No association between APOE and major depressive disorder in a community sample of 17,507 adults.

TitleNo association between APOE and major depressive disorder in a community sample of 17,507 adults.
Publication TypeJournal Article
Year of Publication2009
AuthorsSurtees, PG, Wainwright, NWJ, Bowman, R, Luben, RN, Wareham, NJ, Khaw, K-T, Bingham, SA
JournalJ Psychiatr Res
Volume43
Issue9
Pagination843-7
Date Published2009 Jun
ISSN1879-1379
KeywordsAdult, Aged, Apolipoproteins E, Depressive Disorder, Major, Emotions, European Continental Ancestry Group, Female, Genotype, Humans, Linear Models, Male, Middle Aged, Polymerase Chain Reaction, Prevalence, Risk Factors, United Kingdom
Abstract

Mood-related phenotypes are commonly comorbid with, and have been implicated in the development of, neurological disorders. APOE is a major susceptibility gene for neurodegeneration. Recent evidence from case-control studies has suggested that the apoE 2 allele is associated with major depressive disorder (MDD). However, evidence from large-scale community-based studies is limited. APOE was genotyped for 17,507 men and women, aged 41-80 years, participating in the European Prospective Investigation into Cancer-Norfolk study, who had also completed a psychosocial assessment that included measures of emotional health status defined by MDD, psychological distress (as represented by the Mental Health Inventory, MHI-5), and by an assessment of neuroticism. No associations were found between APOE genotypes and measures either of past-year or lifetime MDD, or of emotional health defined according to the MHI-5 or by neuroticism. Data from this large-scale, community-based, study are not supportive of an association between either MDD or associated measures of emotional state and APOE genotype. These findings suggest that the association between APOE and MDD risk is more modest than has been previously reported.

DOI10.1016/j.jpsychires.2008.12.001
Alternate JournalJ Psychiatr Res
Citation Key10.1016/j.jpsychires.2008.12.001
PubMed ID19135213
Grant List / / British Heart Foundation / United Kingdom
/ / Department of Health / United Kingdom
MC_U105630924 / / Medical Research Council / United Kingdom
MC_U106179471 / / Medical Research Council / United Kingdom
G9502233 / / Medical Research Council / United Kingdom
G0401527 / / Medical Research Council / United Kingdom
C865/A2883 / / Cancer Research UK / United Kingdom
G0300128 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom