Mitochondrial pharmacology.

TitleMitochondrial pharmacology.
Publication TypeJournal Article
Year of Publication2012
AuthorsSmith, RAJ, Hartley, RC, Cochemé, HM, Murphy, MP
JournalTrends Pharmacol Sci
Volume33
Issue6
Pagination341-52
Date Published2012 Jun
ISSN1873-3735
KeywordsApoptosis, Calcium, Drug Discovery, Humans, Mitochondria, Mitochondrial Diseases, Mitochondrial Proteins, Molecular Targeted Therapy, Oxidative Phosphorylation, Protective Agents, Reactive Oxygen Species
Abstract

Mitochondria are being recognized as key factors in many unexpected areas of biomedical science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it is now clear that mitochondria are also central to cell death, neoplasia, cell differentiation, the innate immune system, oxygen and hypoxia sensing, and calcium metabolism. Disruption to these processes contributes to a range of human pathologies, making mitochondria a potentially important, but currently seemingly neglected, therapeutic target. Mitochondrial dysfunction is often associated with oxidative damage, calcium dyshomeostasis, defective ATP synthesis, or induction of the permeability transition pore. Consequently, therapies designed to prevent these types of damage are beneficial and can be used to treat many diverse and apparently unrelated indications. Here we outline the biological properties that make mitochondria important determinants of health and disease, and describe the pharmacological strategies being developed to address mitochondrial dysfunction.

DOI10.1016/j.tips.2012.03.010
Alternate JournalTrends Pharmacol. Sci.
Citation Key10.1016/j.tips.2012.03.010
PubMed ID22521106
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom