Radiosynthesis of 11-[(18) F]fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer.

TitleRadiosynthesis of 11-[(18) F]fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi, L, Brichard, L, Larsen, L, Menon, DK, Smith, RAJ, Murphy, MP, Aigbirhio, FI
JournalJ Labelled Comp Radiopharm
Volume56
Issue14
Pagination717-21
Date Published2013 Dec
ISSN1099-1344
KeywordsFluorine Radioisotopes, Isotope Labeling, Mitochondria, Organophosphorus Compounds, Positron-Emission Tomography, Radiopharmaceuticals
Abstract

Changes in the magnitude of the mitochondrial membrane potential occur in a range of important pathologies. To assess changes in membrane potential in patients, we set out to develop an improved mitochondria-targeted positron emission tomography probe comprising a lipophilic triphenylphosphonium cation attached to a fluorine-18 radionuclide via an 11-carbon alkyl chain, which is well-established to effectively transport to and localise within mitochondria. Here, we describe the radiosynthesis of this probe, 11-[(18) F]fluoroundecyl-triphenylphosphonium (MitoF), from no-carrier-added [(18) F]fluoride and a fully automated synthetic protocol to prepare it in good radiochemical yields (2-3 GBq at end-of-synthesis) and radiochemical purity (97-99%).

DOI10.1002/jlcr.3109
Alternate JournalJ Labelled Comp Radiopharm
Citation Key10.1002/jlcr.3109
PubMed ID24339010
Grant ListG0001354 / / Medical Research Council / United Kingdom
MR/K02308X/1 / / Medical Research Council / United Kingdom
A853-0125 / / Medical Research Council / United Kingdom
MC_U105663142 / / Medical Research Council / United Kingdom
RG46503 / / Medical Research Council / United Kingdom