Redox Homeostasis and Mitochondrial Dynamics.

TitleRedox Homeostasis and Mitochondrial Dynamics.
Publication TypeJournal Article
Year of Publication2015
AuthorsWillems, PHGM, Rossignol, R, Dieteren, CEJ, Murphy, MP, Koopman, WJH
JournalCell Metab
Volume22
Issue2
Pagination207-18
Date Published2015 Aug 04
ISSN1932-7420
KeywordsAnimals, Humans, Mitochondria, Oxidation-Reduction, Reactive Nitrogen Species, Reactive Oxygen Species, Signal Transduction
Abstract

Within living cells, mitochondria are considered relevant sources of reactive oxygen species (ROS) and are exposed to reactive nitrogen species (RNS). During the last decade, accumulating evidence suggests that mitochondrial (dys)function, ROS/RNS levels, and aberrations in mitochondrial morphology are interconnected, albeit in a cell- and context-dependent manner. Here it is hypothesized that ROS and RNS are involved in the short-term regulation of mitochondrial morphology and function via non-transcriptional pathways. We review the evidence for such a mechanism and propose that it allows homeostatic control of mitochondrial function and morphology by redox signaling.

DOI10.1016/j.cmet.2015.06.006
Alternate JournalCell Metab.
Citation Key10.1016/j.cmet.2015.06.006
PubMed ID26166745
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom