Effects of five Ayurvedic herbs on locomotor behaviour in a Drosophila melanogaster Parkinson's disease model.

TitleEffects of five Ayurvedic herbs on locomotor behaviour in a Drosophila melanogaster Parkinson's disease model.
Publication TypeJournal Article
Year of Publication2014
AuthorsJansen, RLM, Brogan, B, Whitworth, AJ, Okello, EJ
JournalPhytother Res
Volume28
Issue12
Pagination1789-95
Date Published2014 Dec
ISSN1099-1573
KeywordsAnimals, Bacopa, Centella, Disease Models, Animal, Drosophila melanogaster, Drosophila Proteins, India, Levodopa, Medicine, Ayurvedic, Motor Activity, Mucuna, Parkinson Disease, Plant Extracts, Plants, Medicinal, Protein-Serine-Threonine Kinases, Withania
Abstract

Current conventional treatments for Parkinson's disease (PD) are aimed at symptom management, as there is currently no known cure or treatment that can slow down its progression. Ayurveda, the ancient medical system of India, uses a combination of herbs to combat the disease. Herbs commonly used for this purpose are Zandopa (containing Mucuna pruriens), Withania somnifera, Centella asiatica, Sida cordifolia and Bacopa monnieri. In this study, these herbs were tested for their potential ability to improve climbing ability of a fruit fly (Drosophila melanogaster) PD model based on loss of function of phosphatase and tensin-induced putative kinase 1 (PINK1). Fruit flies were cultured on food containing individual herbs or herbal formulations, a combination of all five herbs, levodopa (positive control) or no treatment (negative control). Tests were performed in both PINK1 mutant flies and healthy wild-type (WT) flies. A significant improvement in climbing ability was observed in flies treated with B.‚ÄČmonnieri compared with untreated PINK1 mutant flies. However, a significant decrease in climbing ability was observed in WT flies for the same herb. Centella asiatica also significantly decreased climbing ability in WT flies. No significant effects were observed with any of the other herbs in either PINK1 or WT flies compared with untreated flies.

DOI10.1002/ptr.5199
Alternate JournalPhytother Res
Citation Key10.1002/ptr.5199
PubMed ID25091506
PubMed Central IDPMC4310928
Grant List089698 / / Wellcome Trust / United Kingdom
MC_G1000735 / / Medical Research Council / United Kingdom