The many faces of mitophagy.

TitleThe many faces of mitophagy.
Publication TypeJournal Article
Year of Publication2014
AuthorsIvatt, RM, Whitworth, AJ
JournalEMBO Rep
Date Published2014 Jan
KeywordsHumans, Mitochondria, Mitophagy, Protein Kinases, Ubiquitin-Protein Ligases

Failure to maintain mitochondrial integrity is linked to age‐related conditions, such as neurodegeneration. Two genes linked to Parkinson's disease, PINK1 and Parkin, play a key role in targeting the degradation of dysfunctional mitochondria (mitophagy). However, the mechanisms regulating the PINK1/Parkin pathway and other processes that impinge on mitochondrial turnover are poorly understood. Two articles in EMBO reports, by the Przedborski and Ganley groups, shed light on a new role for processed, cytoplasmic PINK1, and show that depletion of cellular iron levels stimulates PINK1/Parkin‐independent mitophagy.

Alternate JournalEMBO Rep.
Citation Key10.1002/embr.201338224
PubMed ID24398127
PubMed Central IDPMC4303441
Grant List089698 / / Wellcome Trust / United Kingdom
MC_G1000735 / / Medical Research Council / United Kingdom