The many faces of mitophagy.

TitleThe many faces of mitophagy.
Publication TypeJournal Article
Year of Publication2014
AuthorsIvatt, RM, Whitworth, AJ
JournalEMBO Rep
Volume15
Issue1
Pagination5-6
Date Published2014 Jan
ISSN1469-3178
KeywordsHumans, Mitochondria, Mitochondrial Degradation, Protein Kinases, Ubiquitin-Protein Ligases
Abstract

Failure to maintain mitochondrial integrity is linked to age‐related conditions, such as neurodegeneration. Two genes linked to Parkinson's disease, PINK1 and Parkin, play a key role in targeting the degradation of dysfunctional mitochondria (mitophagy). However, the mechanisms regulating the PINK1/Parkin pathway and other processes that impinge on mitochondrial turnover are poorly understood. Two articles in EMBO reports, by the Przedborski and Ganley groups, shed light on a new role for processed, cytoplasmic PINK1, and show that depletion of cellular iron levels stimulates PINK1/Parkin‐independent mitophagy.

DOI10.1002/embr.201338224
Alternate JournalEMBO Rep.
Citation Key10.1002/embr.201338224
PubMed ID24398127
PubMed Central IDPMC4303441
Grant List089698 / / Wellcome Trust / United Kingdom
MC_G1000735 / / Medical Research Council / United Kingdom