Drosophila models pioneer a new approach to drug discovery for Parkinson's disease.

TitleDrosophila models pioneer a new approach to drug discovery for Parkinson's disease.
Publication TypeJournal Article
Year of Publication2006
AuthorsWhitworth, AJ, Wes, PD, Pallanck, LJ
JournalDrug Discov Today
Volume11
Issue3-4
Pagination119-26
Date Published2006 Feb
ISSN1359-6446
Keywordsalpha-Synuclein, Animals, Disease Models, Animal, Drosophila melanogaster, Drosophila Proteins, Drug Design, Humans, Nerve Tissue Proteins, Parkinson Disease, Ubiquitin-Protein Ligases
Abstract

Despite the prevalence and severity of Parkinson's disease (PD), little is known about the molecular etiology of this disease, and preventative and disease-modifying therapies remain elusive. Recently, linkage studies have begun to identify single-gene mutations that are responsible for rare, heritable forms of PD, which offer an opportunity to gain insight into the molecular mechanisms of this disorder through the creation and analysis of appropriate animal models. One model system that is tractable for these studies is the fruit fly, Drosophila melanogaster. Analysis of several Drosophila models of PD has revealed some surprising insights into the pathogenesis of PD and begun to highlight potential treatment strategies.

DOI10.1016/S1359-6446(05)03693-7
Alternate JournalDrug Discov. Today
Citation Key10.1016/S1359-6446(05)03693-7
PubMed ID16533709