Gaining mass: the structure of respiratory complex I-from bacterial towards mitochondrial versions.

TitleGaining mass: the structure of respiratory complex I-from bacterial towards mitochondrial versions.
Publication TypeJournal Article
Year of Publication2015
AuthorsLetts, JA, Sazanov, LA
JournalCurr Opin Struct Biol
Volume33
Pagination135-45
Date Published2015 Aug
ISSN1879-033X
Abstract

The 1MDa, 45-subunit proton-pumping NADH-ubiquinone oxidoreductase (complex I) is the largest complex of the mitochondrial electron transport chain. The molecular mechanism of complex I is central to the metabolism of cells, but has yet to be fully characterized. The last two years have seen steady progress towards this goal with the first atomic-resolution structure of the entire bacterial complex I, a 5Å cryo-electron microscopy map of bovine mitochondrial complex I and a ∼3.8Å resolution X-ray crystallographic study of mitochondrial complex I from yeast Yarrowia lipotytica. In this review we will discuss what we have learned from these studies and what remains to be elucidated.

DOI10.1016/j.sbi.2015.08.008
Alternate JournalCurr. Opin. Struct. Biol.
Citation Key10.1016/j.sbi.2015.08.008
PubMed ID26387075
Grant ListMC_U105674180 / / Medical Research Council / United Kingdom