Mitochondrial Diseases: Shortcuts to Therapies and Therapeutic Shortcuts.

TitleMitochondrial Diseases: Shortcuts to Therapies and Therapeutic Shortcuts.
Publication TypeJournal Article
Year of Publication2016
AuthorsMurphy, MP
JournalMol Cell
Volume64
Issue1
Pagination5-6
Date Published2016 Oct 06
ISSN1097-4164
Abstract

In this issue of Molecular Cell, Barrow et al. (2016) use two complementary approaches-one an assessment of a chemical library, and the other a genome-wide CRISPR screen-that both identify bromodomain-containing protein 4 (Brd4) as a therapeutic target for mtDNA diseases affecting complex I.

DOI10.1016/j.molcel.2016.09.022
Alternate JournalMol. Cell
Citation Key10.1016/j.molcel.2016.09.022
PubMed ID27716487
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom