Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3).

TitleSequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3).
Publication TypeJournal Article
Year of Publication1994
AuthorsYan, WL, Lerner, TJ, Haines, JL, Gusella, JF
JournalGenomics
Volume24
Issue2
Pagination375-7
Date Published1994 Nov 15
ISSN0888-7543
KeywordsAmino Acid Sequence, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 2, Cloning, Molecular, DNA, Complementary, Humans, Mitochondria, Molecular Sequence Data, Proton-Translocating ATPases
Abstract

We describe the cloning, sequence analysis, and chromosomal mapping of a novel mitochondrial ATP synthase subunit 9cDNA, P3. Subunit 9 transports protons across the inner mitochondrial membrane to the F1-ATPase protruding on the matrix side, resulting in the generation of ATP. Sequence analysis of the P3 cDNA reveals only 80% identity with the human subunit 9 genes P1 and P2 in the DNA sequence encoding the mature peptide. However, this sequence predicts a mature protein identical to P1 and P2. The predicted sequence of the P3 leader peptide differs from the P1 and P2 leaders, but retains the "RFS" motif critical for mitochondrial import and maturation. The P3 gene (ATP5G3) maps to chromosome 2.

DOI10.1006/geno.1994.1631
Alternate JournalGenomics
Citation Key10.1006/geno.1994.1631
PubMed ID7698763
Grant ListNS24279 / NS / NINDS NIH HHS / United States
NS32099 / NS / NINDS NIH HHS / United States