Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore.

TitlePhysiologic functions of cyclophilin D and the mitochondrial permeability transition pore.
Publication TypeJournal Article
Year of Publication2013
AuthorsElrod, JW, Molkentin, JD
JournalCirc J
Volume77
Issue5
Pagination1111-22
Date Published2013
ISSN1347-4820
KeywordsAnimals, Apoptosis, Cyclophilins, Energy Metabolism, Humans, Mitochondria, Heart, Mitochondrial Membrane Transport Proteins, Mitochondrial Membranes, Myocardial Reperfusion Injury, Myocytes, Cardiac, Necrosis, Phylogeny, Protein Processing, Post-Translational
Abstract

This review focuses on the role of cyclophilin D (CypD) as a prominent mediator of the mitochondrial permeability transition pore (MPTP) and subsequent effects on cardiovascular physiology and pathology. Although a great number of reviews have been written on the MPTP and its effects on cell death, we focus on the biology surrounding CypD itself and the non-cell death physiologic functions of the MPTP. A greater understanding of the physiologic functions of the MPTP and its regulation by CypD will likely suggest novel therapeutic approaches for cardiovascular disease, both dependent and independent of programmed necrotic cell death mechanisms.  

DOI10.1253/circj.CJ-13-0321
Alternate JournalCirc. J.
Citation Key10.1253/circj.CJ-13-0321
PubMed ID23538482
Grant List / / Howard Hughes Medical Institute / United States