Mitochondrial Dynamics: ER Actin Tightens the Drp1 Noose.

TitleMitochondrial Dynamics: ER Actin Tightens the Drp1 Noose.
Publication TypeJournal Article
Year of Publication2016
AuthorsPrudent, J, McBride, HM
JournalCurr Biol
Volume26
Issue5
PaginationR207-9
Date Published2016 Mar 07
ISSN1879-0445
KeywordsActins, Animals, Endoplasmic Reticulum, GTP Phosphohydrolases, Microtubule-Associated Proteins, Mitochondria, Mitochondrial Dynamics, Mitochondrial Proteins
Abstract

Drp1 is an oligomeric GTPase essential for mitochondrial division. A recent study has proposed a new model whereby machinery localized to the endoplasmic reticulum drives polymerization of actin, which then acts as a platform for Drp1 oligomerization and hydrolysis at mitochondrial constriction sites.

DOI10.1016/j.cub.2016.01.009
Alternate JournalCurr. Biol.
Citation Key10.1016/j.cub.2016.01.009
PubMed ID26954442