The Enigma of the Respiratory Chain Supercomplex.

TitleThe Enigma of the Respiratory Chain Supercomplex.
Publication TypeJournal Article
Year of Publication2017
AuthorsMilenkovic, D, Blaza, JN, Larsson, N-G, Hirst, J
JournalCell Metab
Volume25
Issue4
Pagination765-776
Date Published2017 Apr 04
ISSN1932-7420
Abstract

Respiratory chain dysfunction plays an important role in human disease and aging. It is now well established that the individual respiratory complexes can be organized into supercomplexes, and structures for these macromolecular assemblies, determined by electron cryo-microscopy, have been described recently. Nevertheless, the reason why supercomplexes exist remains an enigma. The widely held view that they enhance catalysis by channeling substrates is challenged by both structural and biophysical information. Here, we evaluate and discuss data and hypotheses on the structures, roles, and assembly of respiratory-chain supercomplexes and propose a future research agenda to address unanswered questions.

DOI10.1016/j.cmet.2017.03.009
Alternate JournalCell Metab.
Citation Key10.1016/j.cmet.2017.03.009
PubMed ID28380371