Expression and putative role of mitochondrial transport proteins in cancer.

TitleExpression and putative role of mitochondrial transport proteins in cancer.
Publication TypeJournal Article
Year of Publication2017
AuthorsLytovchenko, O, Kunji, ERS
JournalBiochim Biophys Acta
Volume1858
Issue8
Pagination641-654
Date Published2017 08
ISSN0006-3002
KeywordsBiological Transport, Carrier Proteins, Energy Metabolism, Gene Expression Regulation, Neoplastic, Humans, Mitochondria, Mitochondrial Proteins, Models, Biological, Multigene Family, Neoplasms, Research Design, Tumor Cells, Cultured
Abstract

Cancer cells undergo major changes in energy and biosynthetic metabolism. One of them is the Warburg effect, in which pyruvate is used for fermentation rather for oxidative phosphorylation. Another major one is their increased reliance on glutamine, which helps to replenish the pool of Krebs cycle metabolites used for other purposes, such as amino acid or lipid biosynthesis. Mitochondria are central to these alterations, as the biochemical pathways linking these processes run through these organelles. Two membranes, an outer and inner membrane, surround mitochondria, the latter being impermeable to most organic compounds. Therefore, a large number of transport proteins are needed to link the biochemical pathways of the cytosol and mitochondrial matrix. Since the transport steps are relatively slow, it is expected that many of these transport steps are altered when cells become cancerous. In this review, changes in expression and regulation of these transport proteins are discussed as well as the role of the transported substrates. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.

DOI10.1016/j.bbabio.2017.03.006
Alternate JournalBiochim. Biophys. Acta
Citation Key10.1016/j.bbabio.2017.03.006
PubMed ID28342810