Mitochondria in neuroinflammation - Multiple sclerosis (MS), leber hereditary optic neuropathy (LHON) and LHON-MS.

TitleMitochondria in neuroinflammation - Multiple sclerosis (MS), leber hereditary optic neuropathy (LHON) and LHON-MS.
Publication TypeJournal Article
Year of Publication2017
AuthorsBargiela, D, Chinnery, PF
JournalNeurosci Lett
Date Published2017 Jun 28
ISSN1872-7972
Abstract

Mitochondrial dysfunction is associated with neuroinflammation and neurodegenerative disease, but its role as a driver in these processes is uncertain. Understanding the pathogenesis of inherited mitochondrial disorders may help us to uncover mechanisms involved during acquired mitochondrial dysfunction. We review the mechanisms of mitochondrial dysfunction in Leber's hereditary optic neuropathy and multiple sclerosis and discuss shared clinical and molecular features in both conditions. Targeting mitochondrial pathways involved in inflammation or apoptosis may be a possible therapeutic approach in multiple sclerosis.

DOI10.1016/j.neulet.2017.06.051
Alternate JournalNeurosci. Lett.
Citation Key10.1016/j.neulet.2017.06.051
PubMed ID28668384