|Title||Human mitochondrial ribosomes can switch structural tRNAs - but when and why?|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Chrzanowska-Lightowlers, Z, Rorbach, J, Minczuk, MA|
|Date Published||2017 Aug 08|
High resolution cryoEM of mammalian mitoribosomes revealed the unexpected presence of mitochondrially encoded tRNA as a structural component of mitochondrial large ribosomal subunit (mt-LSU). Our previously published data identified that only mitochondrial (mt-) tRNA(Phe) and mt-tRNA(Val) can be incorporated into mammalian mt-LSU and within an organism there is no evidence of tissue specific variation. When mt-tRNA(Val) is limiting, human mitoribosomes can integrate mt-tRNA(Phe) instead to generate a translationally competent monosome. Here we discuss the possible reasons for and consequences of the observed plasticity of the structural mt-tRNA integration. We also indicate potential direction for further research that could help our understanding of the mechanistic and evolutionary aspects of this unprecedented system.
|Alternate Journal||RNA Biol|