|Title||Calcium and regulation of the mitochondrial permeability transition.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Giorgio, V, Guo, L, Bassot, C, Petronilli, V, Bernardi, P|
|Date Published||2017 May 10|
Recent years have seen renewed interest in the permeability transition pore, a high conductance channel responsible for permeabilization of the inner mitochondrial membrane, a process that leads to depolarization and Ca(2+) release. Transient openings may be involved in physiological Ca(2+) homeostasis while long-lasting openings may trigger and/or execute cell death. In this review we specifically focus (i) on the hypothesis that the PTP forms from the F-ATP synthase and (ii) on the mechanisms through which Ca(2+) can reversibly switch this energy-conserving nanomachine into an energy-dissipating device.
|Alternate Journal||Cell Calcium|