Calcium and regulation of the mitochondrial permeability transition.

TitleCalcium and regulation of the mitochondrial permeability transition.
Publication TypeJournal Article
Year of Publication2017
AuthorsGiorgio, V, Guo, L, Bassot, C, Petronilli, V, Bernardi, P
JournalCell Calcium
Date Published2017 May 10
ISSN1532-1991
Abstract

Recent years have seen renewed interest in the permeability transition pore, a high conductance channel responsible for permeabilization of the inner mitochondrial membrane, a process that leads to depolarization and Ca(2+) release. Transient openings may be involved in physiological Ca(2+) homeostasis while long-lasting openings may trigger and/or execute cell death. In this review we specifically focus (i) on the hypothesis that the PTP forms from the F-ATP synthase and (ii) on the mechanisms through which Ca(2+) can reversibly switch this energy-conserving nanomachine into an energy-dissipating device.

DOI10.1016/j.ceca.2017.05.004
Alternate JournalCell Calcium
Citation Key10.1016/j.ceca.2017.05.004
PubMed ID28522037