Mitochondria-targeted antioxidant MitoQ reduced renal damage caused by ischemia-reperfusion injury in rodent kidneys: Longitudinal observations of T2 -weighted imaging and dynamic contrast-enhanced MRI.

TitleMitochondria-targeted antioxidant MitoQ reduced renal damage caused by ischemia-reperfusion injury in rodent kidneys: Longitudinal observations of T2 -weighted imaging and dynamic contrast-enhanced MRI.
Publication TypeJournal Article
Year of Publication2017
AuthorsLiu, X, Murphy, MP, Xing, W, Wu, H, Zhang, R, Sun, H
JournalMagn Reson Med
Date Published2017 Jun 12
ISSN1522-2594
Abstract

PURPOSE: To investigate the effect of mitochondria-targeted antioxidant MitoQ in reducing the severity of renal ischemia-reperfusion injury (IRI) in rats using T2 -weighted imaging and dynamic contrast-enhanced MRI (DCE-MRI).

METHODS: Ischemia-reperfusion injury was induced by temporarily clamping the left renal artery. Rats were pretreated with MitoQ or saline. The MRI examination was performed before and after IRI (days 2, 5, 7, and 14). The T2 -weighted standardized signal intensity of the outer stripe of the outer medulla (OSOM) was measured. The unilateral renal clearance rate kcl was derived from DCE-MRI. Histopathology was evaluated after the final MRI examination.

RESULTS: The standardized signal intensity of the OSOM on IRI kidneys with MitoQ were lower than those with saline on days 5 and 7 (P = 0.004, P 

CONCLUSIONS: These findings demonstrate that MitoQ can reduce the severity of renal damage in rodent IRI models using T2 -weighted imaging and DCE-MRI. Magn Reson Med, 2017. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

DOI10.1002/mrm.26772
Alternate JournalMagn Reson Med
Citation Key10.1002/mrm.26772
PubMed ID28608403