Childhood-onset Leber hereditary optic neuropathy.

TitleChildhood-onset Leber hereditary optic neuropathy.
Publication TypeJournal Article
Year of Publication2017
AuthorsMajander, A, Bowman, R, Poulton, J, Antcliff, RJ, M Reddy, A, Michaelides, M, Webster, AR, Chinnery, PF, Votruba, M, Moore, AT, Yu-Wai-Man, P
JournalBr J Ophthalmol
Volume101
Issue11
Pagination1505-1509
Date Published2017 Nov
ISSN1468-2079
KeywordsAge of Onset, Child, Child, Preschool, Disease Progression, Female, Genetic Predisposition to Disease, Humans, Male, Optic Atrophy, Hereditary, Leber, Prognosis, Retrospective Studies, United Kingdom, Visual Acuity
Abstract

BACKGROUND: The onset of Leber hereditary optic neuropathy (LHON) is relatively rare in childhood. This study describes the clinical and molecular genetic features observed in this specific LHON subgroup.

METHODS: Our retrospective study consisted of a UK paediatric LHON cohort of 27 patients and 69 additional cases identified from a systematic review of the literature. Patients were included if visual loss occurred at the age of 12 years or younger with a confirmed pathogenic mitochondrial DNA mutation: m.3460G>A, m.11778G>A or m.14484T>C.

RESULTS: In the UK paediatric LHON cohort, three patterns of visual loss and progression were observed: (1) classical acute (17/27, 63%); (2) slowly progressive (4/27, 15%); and (3) insidious or subclinical (6/27, 22%). Diagnostic delays of 3-15 years occurred in children with an insidious mode of onset. Spontaneous visual recovery was more common in patients carrying the m.3460G>A and m.14484T>C mutations compared with the m.11778G>A mutation. Based a meta-analysis of 67 patients with available visual acuity data, 26 (39%) patients achieved a final best-corrected visual acuity (BCVA) ≥0.5 Snellen decimal in at least one eye, whereas 13 (19%) patients had a final BCVA

CONCLUSIONS: Although childhood-onset LHON carries a relatively better visual prognosis, approximately 1 in 5 patients will remain within the visual acuity criteria for legal blindness in the UK. The clinical presentation can be insidious and LHON should be considered in the differential diagnosis when faced with a child with unexplained subnormal vision and optic disc pallor.

DOI10.1136/bjophthalmol-2016-310072
Alternate JournalBr J Ophthalmol
Citation Key10.1136/bjophthalmol-2016-310072
PubMed ID28314831