Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice.

TitleMitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice.
Publication TypeJournal Article
Year of Publication2018
AuthorsGioscia-Ryan, RA, Battson, ML, Cuevas, LM, Eng, JS, Murphy, MP, Seals, DR
JournalJ Appl Physiol (1985)
Volume124
Issue5
Pagination1194-1202
Date Published2018 May 01
ISSN1522-1601
Abstract

Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive dysfunction, and other chronic disorders of aging. Mitochondria-derived reactive oxygen species are a key source of arterial oxidative stress, which may contribute to arterial stiffening by promoting adverse structural changes-including collagen overabundance and elastin degradation-and enhancing inflammation, but the potential for mitochondria-targeted therapeutic strategies to ameliorate aortic stiffening with primary aging is unknown. We assessed aortic stiffness [pulse-wave velocity (aPWV)], ex vivo aortic intrinsic mechanical properties [elastic modulus (EM) of collagen and elastin regions], and aortic protein expression in young (~6 mo) and old (~27 mo) male C57BL/6 mice consuming normal drinking water (YC and OC) or water containing mitochondria-targeted antioxidant MitoQ (250 µM; YMQ and OMQ) for 4 wk. Both baseline and postintervention aPWV values were higher in OC vs. YC (post: 482 ± 21 vs. 420 ± 5 cm/s, P

DOI10.1152/japplphysiol.00670.2017
Alternate JournalJ. Appl. Physiol.
Citation Key10.1152/japplphysiol.00670.2017
PubMed ID29074712
PubMed Central IDPMC6008077
Grant ListMC_U105663142 / / Medical Research Council / United Kingdom