Mitochondrial transcription and translation: overview.

TitleMitochondrial transcription and translation: overview.
Publication TypeJournal Article
Year of Publication2018
AuthorsD'Souza, AR, Minczuk, MA
JournalEssays Biochem
Volume62
Issue3
Pagination309-320
Date Published2018 Jul 20
ISSN1744-1358
Abstract

Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the inner membrane of the organelle are involved in the oxidative phosphorylation required for ATP production. Thirteen subunits of these complexes are encoded by the mitochondrial genome often referred to as mtDNA. For this reason, the expression of mtDNA is vital for the assembly and functioning of the oxidative phosphorylation complexes. Defects of the mechanisms regulating mtDNA gene expression have been associated with deficiencies in assembly of these complexes, resulting in mitochondrial diseases. Recently, numerous factors involved in these processes have been identified and characterized leading to a deeper understanding of the mechanisms that underlie mitochondrial diseases.

DOI10.1042/EBC20170102
Alternate JournalEssays Biochem.
Citation Key10.1042/EBC20170102
PubMed ID30030363
PubMed Central IDPMC6056719