The mammalian mitochondrial epitranscriptome.

TitleThe mammalian mitochondrial epitranscriptome.
Publication TypeJournal Article
Year of Publication2019
AuthorsRebelo-Guiomar, P, Powell, CA, Van Haute, L, Minczuk, M
JournalBiochim Biophys Acta Gene Regul Mech
Volume1862
Issue3
Pagination429-446
Date Published2019 Mar
ISSN1876-4320
Abstract

Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been emerging as an important regulatory feature of mitochondrial gene expression. Here we review the current knowledge on how the mammalian mitochondrial epitranscriptome participates in regulating mitochondrial homeostasis. In particular, we focus on the latest breakthroughs made towards understanding the roles of the modified nucleotides in mitochondrially-encoded ribosomal and transfer RNAs, the enzymes responsible for introducing these modifications and on recent transcriptome-wide studies reporting modifications to mitochondrial messenger RNAs. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Matthias Soller and Dr. Rupert Fray.

DOI10.1016/j.bbagrm.2018.11.005
Alternate JournalBiochim Biophys Acta Gene Regul Mech
Citation Key10.1016/j.bbagrm.2018.11.005
PubMed ID30529456
PubMed Central IDPMC6414753