Structural changes in the transport cycle of the mitochondrial ADP/ATP carrier.

TitleStructural changes in the transport cycle of the mitochondrial ADP/ATP carrier.
Publication TypeJournal Article
Year of Publication2019
AuthorsRuprecht, JJ, Kunji, ERS
JournalCurr Opin Struct Biol
Volume57
Pagination135-144
Date Published2019 Apr 27
ISSN1879-033X
Abstract

The mitochondrial ADP/ATP carrier, also called adenine nucleotide translocase, accomplishes one of the most important transport activities in eukaryotic cells, importing ADP into the mitochondrial matrix for ATP synthesis, and exporting ATP to fuel cellular activities. In the transport cycle, the carrier changes between a cytoplasmic and matrix state, in which the central substrate binding site is alternately accessible to these compartments. A structure of a cytoplasmic state was known, but recently, a structure of a matrix-state in complex with bongkrekic acid was solved. Comparison of the two states explains the function of highly conserved sequence features and reveals that the transport mechanism is unique, involving the coordinated movement of six dynamic elements around a central translocation pathway.

DOI10.1016/j.sbi.2019.03.029
Alternate JournalCurr. Opin. Struct. Biol.
Citation Key10.1016/j.sbi.2019.03.029
PubMed ID31039524