Mitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery.

TitleMitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery.
Publication TypeJournal Article
Year of Publication2019
AuthorsKanagasundaram, NS, Baudouin, SV, Rowling, S, Prabhu, M, Dark, JH, Goodship, THJ, Chinnery, PF, Hudson, G
JournalSci Rep
Volume9
Issue1
Pagination2279
Date Published2019 Feb 19
ISSN2045-2322
Abstract

Although mitochondrial dysfunction plays a key role in the pathophysiology of acute kidney injury (AKI), the influence of mitochondrial genetic variability in this process remains unclear. We explored the association between the risk of post-cardiac bypass AKI and mitochondrial haplotype - inherited mitochondrial genomic variations of potentially functional significance. Our single-centre study recruited consecutive patients prior to surgery. Exclusions included stage 5 CKD, non-Caucasian race and subsequent off-pump surgery. Haplogroup analysis allowed characterisation of the study population using the common mutations and by phylogenetic supergroup (WXI and HV). Chi-square tests for association allowed the identification of potential predictors of AKI for use in logistic regression analysis. AKI occurred in 12.8% of the study population (n = 881; male 69.6%, non-diabetic 78.5%, median (interquartile range) age 68.0 (61.0-75.0) years). The haplogroup profile comprised H (42.7%), J (12.1%), T (10.9%), U (14.4%) and K (7.6%). Although the regression model was statistically significant (χ = 95.483, p 

DOI10.1038/s41598-018-37944-2
Alternate JournalSci Rep
Citation Key10.1038/s41598-018-37944-2
PubMed ID30783114
PubMed Central IDPMC6381211