Mitochondrial DNA: the overlooked oncogenome?

TitleMitochondrial DNA: the overlooked oncogenome?
Publication TypeJournal Article
Year of Publication2019
AuthorsGammage, PA, Frezza, C
JournalBMC Biol
Volume17
Issue1
Pagination53
Date Published2019 07 08
ISSN1741-7007
Abstract

Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad biochemical causes, a historically neglected source is that of the mitochondrial genome. Recent large-scale sequencing efforts and clinical studies have highlighted the prevalence of mutations in mitochondrial DNA (mtDNA) in human tumours and their potential roles in cancer progression. In this review we discuss the biology of the mitochondrial genome, sources of mtDNA mutations, and experimental evidence of a role for mtDNA mutations in cancer. We also propose a 'metabolic licensing' model for mtDNA mutation-derived dysfunction in cancer initiation and progression.

DOI10.1186/s12915-019-0668-y
Alternate JournalBMC Biol.
Citation Key10.1186/s12915-019-0668-y
PubMed ID31286943
PubMed Central IDPMC6615100
Grant ListMC_UU_00015/4 / / Medical Research Council / United Kingdom
MC_UU_12022/6 / / Medical Research Council / United Kingdom