|Title||Physical and Functional Cross Talk Between Endo-Sarcoplasmic Reticulum and Mitochondria in Skeletal Muscle.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Boncompagni, S, Pozzer, D, Viscomi, C, Ferreiro, A, Zito, E|
|Journal||Antioxid Redox Signal|
|Date Published||2019 Dec 11|
The physiological relevance of contacts between the sarcoplasmic reticulum (SR), a specialized domain of the endoplasmic reticulum (ER) in skeletal muscle, and mitochondria is still not clear. An extensive close proximity of these two organelles is a late developmental event, which suggests that it does not have an essential function. The intimate association of SR/mitochondria develops during murine postnatal differentiation and the recovery of denervated atrophic muscle, which suggests that this is a highly regulated process with a specific function. Analyses of mouse models for muscle diseases suggest that impaired ER/SR-mitochondrial contacts may be due to ER stress and lead to defective bioenergetics and insulin signaling. Future studies are necessary to identify the molecular determinants weakening insulin signaling upon impairment of ER/mitochondrial contacts in skeletal muscles as well as to analyze the distance between SR/ER and mitochondria in muscle diseases associated with ER stress.
|Alternate Journal||Antioxid. Redox Signal.|