Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential.

TitleAngiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential.
Publication TypeJournal Article
Year of Publication2019
AuthorsWhitehead, M, Osborne, A, Widdowson, PS, Yu-Wai-Man, P, Martin, KR
JournalJ Diabetes Res
Volume2019
Pagination5140521
Date Published2019
ISSN2314-6753
KeywordsAngiopoietins, Animals, Diabetes Complications, Diabetes Mellitus, Diabetic Retinopathy, Humans, Hypoglycemic Agents, Macular Edema, Signal Transduction
Abstract

Diabetic retinopathy (DR) is the commonest cause of blindness in the working-age population of the developed world. The molecular pathophysiology of DR is complex, and a complete spatiotemporal model of the disease is still being elucidated. Recently, a role for angiopoietin (Ang) proteins in the pathophysiology of DR has been proposed by several research groups, and several aspects of Ang signalling are being explored as novel therapeutic strategies. Here, we review the role of the Ang proteins in two important forms of DR, diabetic macular oedema and proliferative diabetic retinopathy. The function of the Ang proteins in regulating blood vessel permeability and neovascularisation is discussed, and we also evaluate recent preclinical and clinical studies highlighting the potential benefits of modulating Ang signalling as a treatment for DR.

DOI10.1155/2019/5140521
Alternate JournalJ Diabetes Res
Citation Key10.1155/2019/5140521
PubMed ID31485452
PubMed Central IDPMC6710771