|Title||Chronic pain is common in mitochondrial disease.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||van den Ameele, J, Fuge, J, Pitceathly, RDS, Berry, S, McIntyre, Z, Hanna, MG, Lee, M, Chinnery, PF|
|Date Published||2020 Feb 29|
In the absence of cure, the main objectives in the management of patients with mitochondrial disease are symptom control and prevention of complications. While pain is a complicating symptom in many chronic diseases and is known to have a clear impact on quality of life, its prevalence and severity in people with mitochondrial disease is unknown. We conducted a survey of pain symptoms in patients with genetically confirmed mitochondrial disease from two UK mitochondrial disease specialist centres. The majority (66.7%) of patients had chronic pain which was primarily of neuropathic nature. Presence of pain did not significantly impact overall quality of life. The m.3243A>G MTTL1 mutation was associated with higher pain severity and increased the likelihood of neuropathic pain compared to other causative nuclear and mitochondrial gene mutations. Although previously not considered a core symptom in people with mitochondrial disease, pain is a common clinical manifestation, frequently of neuropathic nature, and influenced by genotype. Therefore, pain-related symptoms should be carefully characterised and actively managed in this patient population.
|Alternate Journal||Neuromuscul. Disord.|