Mitochondrial Calcium Handling in Physiology and Disease.

TitleMitochondrial Calcium Handling in Physiology and Disease.
Publication TypeJournal Article
Year of Publication2017
AuthorsGranatiero, V, De Stefani, D, Rizzuto, R
JournalAdv Exp Med Biol
Volume982
Pagination25-47
Date Published2017
ISSN0065-2598
KeywordsAnimals, Calcium, Calcium Signaling, Cell Death, Disease, Energy Metabolism, Homeostasis, Humans, Mitochondria, Mitochondrial Diseases, Time Factors
Abstract

Calcium (Ca) accumulation inside mitochondria represents a pleiotropic signal controlling a wide range of cellular functions, including key metabolic pathways and life/death decisions. This phenomenon has been first described in the 1960s, but the identity of the molecules controlling this process remained a mystery until just few years ago, when both mitochondrial Ca uptake and release systems were genetically dissected. This finally opened the possibility to develop genetic models to directly test the contribution of mitochondrial Ca homeostasis to cellular functions. Here we summarize our current understanding of the molecular machinery that controls mitochondrial Ca handling and critically evaluate the physiopathological role of mitochondrial Ca signaling, based on recent evidences obtained through in vitro and in vivo models.

DOI10.1007/978-3-319-55330-6_2
Alternate JournalAdv. Exp. Med. Biol.
Citation Key10.1007/978-3-319-55330-6_2
PubMed ID28551780