The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders.

TitleThe Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders.
Publication TypeJournal Article
Year of Publication2017
AuthorsLiao, Y, Dong, Y, Cheng, J
JournalInt J Mol Sci
Volume18
Issue2
Date Published2017 Feb 10
ISSN1422-0067
KeywordsAdenosine Triphosphate, Animals, Biological Transport, Calcium, Calcium Channel Blockers, Calcium Channels, Calcium Signaling, Humans, Inflammation, Iron Overload, Mitochondria, Molecular Targeted Therapy, Neurodegenerative Diseases, Neurons, Oxidative Stress, Reactive Oxygen Species, Signal Transduction
Abstract

The mitochondrial calcium uniporter (MCU)-a calcium uniporter on the inner membrane of mitochondria-controls the mitochondrial calcium uptake in normal and abnormal situations. Mitochondrial calcium is essential for the production of adenosine triphosphate (ATP); however, excessive calcium will induce mitochondrial dysfunction. Calcium homeostasis disruption and mitochondrial dysfunction is observed in many neurodegenerative disorders. However, the role and regulatory mechanism of the MCU in the development of these diseases are obscure. In this review, we summarize the role of the MCU in controlling oxidative stress-elevated mitochondrial calcium and its function in neurodegenerative disorders. Inhibition of the MCU signaling pathway might be a new target for the treatment of neurodegenerative disorders.

DOI10.3390/ijms18020248
Alternate JournalInt J Mol Sci
Citation Key10.3390/ijms18020248
PubMed ID28208618
PubMed Central IDPMC5343785